Jun, the oncoprotein.

P K Vogt

doi:10.1038/sj.onc.1204443

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PubMed · 11402333

Jun, the oncoprotein.

P K Vogt

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Abstract

Cellular Jun (c-Jun) and viral Jun (v-Jun) can induce oncogenic transformation. For this activity, c-Jun requires an upstream signal, delivered by the Jun N-terminal kinase (JNK). v-Jun does not interact with JNK; it is autonomous and constitutively active. v-Jun and c-Jun address overlapping but not identical sets of genes. Whether all genes essential for transformation reside within the overlap of the v-Jun and c-Jun target spectra remains to be determined. The search for transformation-relevant targets of Jun is moving into a new stage with the application of DNA microarrays technology. Genetic screens and functional tests remain a necessity for the identification of genes that control the oncogenic phenotype.

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Animals Cell Transformation, Neoplastic Consensus Sequence DNA-Binding Proteins Dimerization G-Box Binding Factors Gene Expression Profiling Mutation Oncogene Protein p65(gag-jun)Proto-Oncogene Proteins c-jun Transcription Factor AP-1 Transcription Factors Transcriptional Activation Journal Article Research Support, U.S. Gov't, P.H.S.Review

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P K Vogt. 2001-04-30. Jun, the oncoprotein.. https://doi.org/10.1038/sj.onc.1204443

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