Signaling pathways and effector mechanisms pre-programmed cell death.

N B Blatt; G D Glick

doi:10.1016/s0968-0896(01)00041-4

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Signaling pathways and effector mechanisms pre-programmed cell death.

N B Blatt·G D Glick

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Abstract

Apoptosis is a complex biochemical process that involves all aspects of the cell from the plasma membrane to the nucleus. Apoptosis stimuli are mediated by many different cellular processes including protein synthesis and degradation, the alteration in protein phosphorylation states, the activation of lipid second messenger systems, and disruption of normal mitochondrial function. Despite this diversity in signal transduction, all apoptotic pathways are believed to converge ultimately with the activation of caspases leading to the characteristic morphological changes of apoptosis. In this review, we discuss what is known about these pathways and its implication for normal cellular function.

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Animals Apoptosis Caspases Cell Death Ceramides Humans Mitochondria Phosphoprotein Phosphatases Protein Kinases Proto-Oncogene Proteins c-bcl-2 Signal Transduction Tumor Suppressor Protein p53 Journal Article Research Support, U.S. Gov't, P.H.S.Review

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N B Blatt, G D Glick. 2001. Signaling pathways and effector mechanisms pre-programmed cell death.. https://doi.org/10.1016/s0968-0896(01)00041-4

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