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PubMed · 11411264

Monitoring micronutrient deficiency conditions.

G G Harrison
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Abstract

Data for monitoring of nutritional status need to be selected and interpreted with as much care as goes into the quality control for their collection. Cost and efficiency need to be considered as well as interpretability. Few indices of nutritional status are completely specific, and those that are reasonably specific tend to be not very sensitive. As progress toward the control of micronutrient deficiency conditions occurs, the focus needs to be on early indicators of deficiency and risk, and on risk factors including dietary intake.

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Deficiency DiseasesDietHumansMass ScreeningMicronutrientsNutrition SurveysNutritive ValueJournal ArticleReview

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G G Harrison. 2000. Monitoring micronutrient deficiency conditions.. https://pubmed.ncbi.nlm.nih.gov/11411264/

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Omega-3 fatty acid deficiency in major depressive disorder is caused by the interaction between diet and a genetically determined abnormality in phospholipid metabolism.

Omega-3 fatty acids are a type of polyunsaturated fatty acid (PUFA). A growing body of evidence suggests that this form PUFA is a useful and well tolerated treatment for major depressive disorder, a common and serious mental illness. The efficacy of omega-3 PUFA is routinely explained as being due to a deficiency caused by inadequate dietary intake of this class of fatty acid. The hypothesis considered states that low omega-3 PUFA abundance in patients with major depressive and related disorders is due to an underlying genetically determined abnormality. The hypothesis can explain why although a specific and consistent deficit in omega-3, but not omega-6, PUFA occurs in major depressive and related disorders, the literature does not consistently support the notion that this is due to deficient dietary intake. Specifically it is hypothesized that having genetically determined low activity of fatty acid CoA ligase 4 and/or Type IV phospholipase A(2) combined with the low dietary availability of omega-3 PUFA results in reduced cellular uptake of omega-3 PUFA and constitutes a risk factor for depression. The hypothesis also has important consequences for the pharmacological treatment of depression in that it predicts that administering agents which enhance phospholipid synthesis, particularly those containing ethanolamine such as CDP-ethanolamine, should be effective antidepressants especially when co-administered with omega-3 PUFA.

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