Factor VIIIa-induced gene expression: potential implications in pathophysiology.

L V Rao; U R Pendurthi

doi:10.1016/s1050-1738(01)00077-9

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Factor VIIIa-induced gene expression: potential implications in pathophysiology.

L V Rao·U R Pendurthi

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Abstract

Binding of factor VIIa (VIIa) to tissue factor (TF) triggers the coagulation cascade. Several studies indicate a possible role for TF-VIIa in other cellular functions, in addition to coagulation, under pathophysiological conditions. Recent studies suggest that TF-VIIa mediates cell signaling by two distinct mechanisms, TF cytoplasmic domain-dependent and TF-VIIa protease activity-dependent. In this review, we focus upon TF-VIIa protease-induced gene expression and how the altered gene expression could potentially affect various cellular processes.

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Animals Endothelial Growth Factors Extracellular Matrix Proteins Factor VIIa Fibroblasts Gene Expression Humans Lymphokines Signal Transduction Thromboplastin Up-Regulation Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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L V Rao, U R Pendurthi. 2001. Factor VIIIa-induced gene expression: potential implications in pathophysiology.. https://doi.org/10.1016/s1050-1738(01)00077-9

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