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PubMed · 11414273

Dendritic morphogenesis: building an arbor.

S McFarlane
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Abstract

Neurons are polarized cells with an axon and a dendritic arbor extending from the soma. Although the molecular mechanisms underlying axon guidance are rapidly being elucidated, those that regulate the orientation, morphology, and elaboration of dendritic processes are largely unknown. Several recent papers address these issues, and propose a set of molecular strategies that control dendrite development. This review discusses these papers and what they reveal to us about how cell signaling orchestrates neuronal form and connectivity during development.

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AnimalsBrain-Derived Neurotrophic FactorCell PolarityCell SizeChemotactic FactorsDendritesGenes, ReporterGlycoproteinsGuanylate CyclaseHumansMembrane ProteinsMiceMice, KnockoutMice, TransgenicModels, NeurologicalMorphogenesisNerve Tissue ProteinsPyramidal CellsRatsReceptor, trkBReceptors, NotchSemaphorin-3ASignal TransductionXenopus laevisJournal ArticleReview

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S McFarlane. Dendritic morphogenesis: building an arbor.. https://doi.org/10.1385/mn%3A22%3A1-3%3A001

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