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PubMed · 11416918

Olfactory coding in a simple system: adaptation in Drosophila larvae.

M Cobb·I Domain
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Abstract

Drosophila melanogaster larvae were pre-stimulated with high concentrations of six homologous alcohols (C4-C9) and then tested for adaptation and cross-adaptation using these same alcohols, four aliphatic n-acetates and three acids. Pre-stimulation with hexanol effectively reduced to zero (abolished) test responses to all six alcohols, whereas test responses to hexanol were only affected by pre-stimulation with hexanol. This substance appears to play a fundamental role in the organization of the larval olfactory system. Test responses to butanol and pentanol, and the effect of pre-stimulation with butanol and pentanol, were not significantly different, indicating that they are sensory equivalents. Heptanol, octanol and nonanol induce a complex set of responses among one another. Cross-adaptation between functional groups was observed, in particular following pre-stimulation with hexanol, but there was also evidence that functional groups are coded separately. A model of olfactory processing in the fruitfly maggot is presented that explains the data and provides predictions for future anatomical, genetic and electrophysiological studies.

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AcetatesAcidsAdaptation, PhysiologicalAlcoholsAnimalsDrosophila melanogasterLarvaModels, BiologicalOlfactory Receptor NeuronsSmellJournal Article

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M Cobb, I Domain. 2000-10-22. Olfactory coding in a simple system: adaptation in Drosophila larvae.. https://doi.org/10.1098/rspb.2000.1258

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