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Relationship between circulating high density lipoprotein concentrations and interleukin-6 release during abdominal operations.

T Fujita·A Hara·Y Yamazaki
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Abstract

OBJECTIVE: To investigate whether circulating high density lipoprotein (HDL) concentrations influence inflammatory cytokine release during abdominal operations. SETTING: University Hospital, Japan. PATIENTS: 30 patients who underwent curative operations for gastric cancer. MAIN OUTCOME MEASURES: Serum HDL and cytokine concentrations were measured preoperatively, and portal and systemic blood samples were taken for the analysis of cytokine and endotoxin concentrations during operations. RESULTS: Portal blood interleukin-6 (IL-6) values of patients with low serum HDL concentrations (n = 6) (< 0.9 mmol/L) were significantly (p < 0.01) higher than those in patients with normal or high HDL concentrations (n = 24) (> or = 0.9 mmol/L) (80.63 (74.62) pg/ml (mean (SD)) compared with 10.25 (9.61) pg/ml.). Moreover, an inverse correlation (r = -0.43, p < 0.05) was found between portal blood IL-6 concentrations and circulating HDL concentrations. CONCLUSIONS: We suggest that serum HDL concentrations influence IL-6 release in response to abdominal operations. Circulating HDL particles may reduce endotoxin-induced IL-6 release in humans.

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AgedCholesterol, HDLFemaleGastrectomyHumansInterleukin-6MaleMiddle AgedStomach NeoplasmsStress, PhysiologicalJournal Article

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T Fujita, A Hara, Y Yamazaki. 2001. Relationship between circulating high density lipoprotein concentrations and interleukin-6 release during abdominal operations.. https://doi.org/10.1080/110241501750215212

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