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PubMed · 11421286

Translational regulation by ABC systems.

K Chakraburtty
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Abstract

Elongation factor 3 is a cytosolic protein required by the fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates binding of EF-1:GTP:aa-tRNA ternary complex to the ribosomal A site by facilitated release of the deacylated tRNA from the E site. The reaction requires ATP hydrolysis. EF-3 contains two ATP binding sequence (NBS) motifs. NBSI is sufficient for the intrinsic ATPase activity. NBSII is essential for the ribosome-stimulated functions.

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ATP-Binding Cassette TransportersAmino Acid SequenceFungal ProteinsGene Expression Regulation, FungalMolecular Sequence DataPeptide Elongation FactorsProtein BiosynthesisRibosomesSaccharomyces cerevisiae ProteinsSequence Homology, Amino AcidYeastsJournal ArticleReview

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K Chakraburtty. Translational regulation by ABC systems.. https://doi.org/10.1016/s0923-2508(01)01210-4

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