Affinity enhancement by multivalent lectin-carbohydrate interaction.

R T Lee; Y C Lee

doi:10.1023/a:1011070425430

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Affinity enhancement by multivalent lectin-carbohydrate interaction.

R T Lee·Y C Lee

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Abstract

The binding of simple carbohydrate ligands by proteins often requires affinity enhancement to attain biologically relevant strength. This is especially true for endocytotic receptors and the molecules that engage in the first-line of defense. For such purposes, nature often utilizes a mode of affinity enhancement that arises from multiple interactions between the binding proteins and the carbohydrate ligands, which we term glycoside cluster effect. In this review article we give a number of examples and describe important factors in the multi-valent interactions that govern the degree of affinity enhancement.

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Animals Binding Sites Carbohydrate Metabolism Carbohydrate Sequence Carbohydrates Galectins Hemagglutinins Lectins Models, Molecular Molecular Conformation Molecular Sequence Data Journal Article Review

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R T Lee, Y C Lee. Affinity enhancement by multivalent lectin-carbohydrate interaction.. https://doi.org/10.1023/a%3A1011070425430

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