Flexible two-stage designs: an overview.

P Bauer; W Brannath; M Posch

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PubMed · 11424295

Flexible two-stage designs: an overview.

P Bauer·W Brannath·M Posch

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Abstract

In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.

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P Bauer, W Brannath, M Posch. 2001. Flexible two-stage designs: an overview.. https://pubmed.ncbi.nlm.nih.gov/11424295/

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