Proteomics--post-genomic cartography to understand gene function.

S Naaby-Hansen; M D Waterfield; R Cramer

doi:10.1016/s0165-6147(00)01663-1

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Proteomics--post-genomic cartography to understand gene function.

S Naaby-Hansen·M D Waterfield·R Cramer

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Abstract

The completion of the genomic sequences of numerous organisms from human and mouse to Caenorhabditis elegans and many microorganisms, and the definition of their genes provides a database to interpret cellular protein-expression patterns and relate them to protein function. Proteomics technologies that are dependent on mass spectrometry and involve two-dimensional gel electrophoresis are providing the main window into the world of differential protein-expression analysis. In this article, the limitations and expectations of this research field are examined and the future of the analytical needs of proteomics is explored.

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Animals Electrophoresis, Gel, Two-Dimensional Humans Mass Spectrometry Peptide Mapping Proteome Sequence Tagged Sites Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Journal Article Review

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S Naaby-Hansen, M D Waterfield, R Cramer. 2001. Proteomics--post-genomic cartography to understand gene function.. https://doi.org/10.1016/s0165-6147(00)01663-1

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