Linking class-switch recombination with somatic hypermutation.

K Kinoshita; T Honjo

doi:10.1038/35080033

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Linking class-switch recombination with somatic hypermutation.

K Kinoshita·T Honjo

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Abstract

The recent discovery of a molecular link between two apparently different genetic alteration events--class-switch recombination and somatic hypermutation--has led to the idea that the recognition and cleavage of target DNA in these two events might be mediated by similar or identical molecules to those involved in RNA editing. This could mean that the complexity of mammalian genetic information may be enriched by an interplay between RNA editing and DNA modification.

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APOBEC-1 Deaminase Animals Cytidine Deaminase DNA Genes, Reporter Germinal Center Immunoglobulin Class Switching Models, Genetic Mutation Nucleic Acid Conformation RNA Editing Recombinant Fusion Proteins Recombination, Genetic AICDA (Activation-Induced Cytidine Deaminase)Journal Article Research Support, Non-U.S. Gov't Review

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K Kinoshita, T Honjo. 2001. Linking class-switch recombination with somatic hypermutation.. https://doi.org/10.1038/35080033

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