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Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate.

J Dopazo·A Mendoza·J Herrero·F Caldara·Y Humbert·L Friedli·M Guerrier·E Grand-Schenk·C Gandin·M de Francesco·A Polissi·G Buell·G Feger·E García·M Peitsch·J F García-Bustos
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Abstract

The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.

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DNA, BacterialGenes, BacterialGenome, BacterialMolecular Sequence DataPneumococcal InfectionsProkaryotic CellsRNA, TransferStreptococcus pneumoniaeJournal Article

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J Dopazo, A Mendoza, J Herrero, F Caldara, Y Humbert, L Friedli, M Guerrier, E Grand-Schenk, C Gandin, M de Francesco, A Polissi, G Buell, G Feger, E García, M Peitsch, J F García-Bustos. 2001. Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate.. https://doi.org/10.1089/10766290152044995

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