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Intracellular Ca2+ release sparks atrial pacemaker activity.

S L Lipsius·J Hüser·L A Blatter
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Abstract

Electrical excitation of the mammalian heart originates from specialized pacemaker cells in the right atrium. Pacemaker activity depends on multiple ion channels and transport mechanisms that reside primarily within the plasma membrane. However, recent evidence indicates that intracellular Ca2+ release from the sarcoplasmic reticulum also contributes importantly to atrial pacemaker function.

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AnimalsAtrial FunctionCalciumCalcium Channels, T-TypeElectric ConductivityHumansIntracellular MembranesSarcoplasmic ReticulumSodium-Calcium ExchangerJournal ArticleReview

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S L Lipsius, J Hüser, L A Blatter. 2001. Intracellular Ca2+ release sparks atrial pacemaker activity.. https://doi.org/10.1152/physiologyonline.2001.16.3.101

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