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Transcriptional reprogramming during T helper cell differentiation.

T M Aune
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Abstract

Our laboratory employs reporter transgenic mice as model systems to study the transcriptional reprogramming that accompanies T helper cell differentiation. These studies demonstrate that changes in the activity of simple transcriptional elements associated with the IFN-gamma gene can recapitulate alterations in gene expression. In addition, our studies have revealed a key role for the transcription factor, CAMP response element binding protein (CREB), in the protection of differentiating T cells from apoptosis. Together, these findings further our understanding of the logic employed by T cells to alter gene expression profiles in response to differentiation signals.

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AnimalsApoptosisBrainCD8-Positive T-LymphocytesCell DifferentiationColforsinCyclic AMPCyclic AMP Response Element-Binding ProteinCyclosporineDNA-Binding ProteinsGene Expression RegulationGenes, ReporterImmunologic MemoryImmunosuppressive AgentsInterferon-gammaInterleukin-12Interleukin-4MemoryMiceMice, TransgenicModels, AnimalModels, BiologicalNFATC Transcription FactorsNuclear ProteinsPromoter Regions, GeneticReceptors, Antigen, T-CellSecond Messenger SystemsT-Lymphocytes, Helper-InducerTranscription FactorsTranscription, GeneticComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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T M Aune. 2001. Transcriptional reprogramming during T helper cell differentiation.. https://doi.org/10.1385/ir%3A23%3A2-3%3A193

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