Age-related changes in the mouse outer retina.

C Li; M Cheng; H Yang; N S Peachey; M I Naash

doi:10.1097/00006324-200106000-00015

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Age-related changes in the mouse outer retina.

C Li·M Cheng·H Yang·N S Peachey·M I Naash

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Abstract

PURPOSE: To define the physiological and structural changes that may accompany aging in the normal mouse retina. METHODS: C57BL/6 mice were maintained under cyclic light for either 2, 6, or 12 months. After rod- and cone-mediated corneal electroretinograms (ERG's) were recorded from anesthetized animals, the retinal structure was quantitatively examined. Photoreceptor cell density was measured within 100-microm regions of the central superior and inferior retina. Cone photoreceptor subtypes were identified by immunocytochemistry. RESULTS: The amplitudes of rod- and cone-mediated ERG's were reduced in older mice, although the overall ERG wave-form did not change appreciably and implicit times were not changed in an age-dependent fashion. In comparison, there was no significant age-related decline in rod or cone photoreceptor density. CONCLUSIONS: The amplitude of the mouse ERG declines with age. This change does not appear to reflect a change in the structural integrity of the photoreceptor cells. In functional studies of murine models of late-onset retinal disorders, it will be important to take these changes into consideration.

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Aging Animals Cell Count Electroretinography Fluorescent Antibody Technique, Indirect Light Mice Mice, Inbred C57BL Photoreceptor Cells, Vertebrate Retina Rod Opsins Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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C Li, M Cheng, H Yang, N S Peachey, M I Naash. 2001. Age-related changes in the mouse outer retina.. https://doi.org/10.1097/00006324-200106000-00015

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