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PubMed · 1144537

Latrogenic platelet dysfunction: an emerging peril.

S A Wolfe·E C Lian
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Abstract

Abnormal bleeding after a face lift was found to be due to a profound interference in platelet function caused by clofibrate and xylocaine acting synergistically. This did not appear to be an idiosyncratic reaction to either of the drugs, as it could be reproduced in vitro by using platelets from normal individuals. Clofibrate is a drug used commonly by persons in the age group requesting face lifts. Beware.

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Blood Coagulation DisordersBlood PlateletsClofibrateDrug SynergismFaceHematomaHumansIatrogenic DiseaseIn Vitro TechniquesLidocaineMaleMiddle AgedPostoperative ComplicationsSurgery, PlasticJournal Article

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S A Wolfe, E C Lian. 1975. Latrogenic platelet dysfunction: an emerging peril.. https://pubmed.ncbi.nlm.nih.gov/1144537/

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[Hemostatic anomalies and coronary risk].

The main role of thrombosis in the acute coronary event is now well documented. Numerous hemostatic factors are involved in thrombosis. Among them, fibrinogen, factor VII, leucocytes and platelets have been shown by epidemiology, to be closely related to the acute coronary event. The key role seems to be reserved to platelets since the close relationship of their activity as evaluated by platelet aggregation tests, to both coronary episodes and the main risk factors such as smoking, diabetes and dietary habits, has been recently demonstrated. In addition, the role of platelets has been confirmed by the marked protective effect against coronary events, of drugs such as aspirin, inhibiting platelet aggregation.

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