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Urinary retention caused after fluoxetine-risperidone combination.

V Bozikas·P Petrikis·A Karavatos
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Abstract

A case of urinary retention emerging after fluoxetine (20 mg/day) addition to low risperidone doses (2 mg/day) is presented. Severe extrapyramidal side-effects (EPS) also occurred after fluoxetine-risperidone combination. Several possibilities, based on the pharmacodynamic and pharmacokinetic properties of risperidone and fluoxetine, which merit consideration in an attempt to explain our patient's side-effects, are discussed. Extrapyramidal side-effects can be due to an increase of the plasma concentration of risperidone and/or the intrinsic propensity of fluoxetine to produce EPS. Urinary retention may be the consequence of a central serotoninergic mechanism in, or without, combination central D2 blockade.

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Antidepressive Agents, Second-GenerationAntipsychotic AgentsBasal Ganglia DiseasesDelusionsDrug CombinationsFluoxetineHumansMaleMiddle AgedRisperidoneUrinary RetentionCase ReportsJournal Article

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V Bozikas, P Petrikis, A Karavatos. 2001. Urinary retention caused after fluoxetine-risperidone combination.. https://doi.org/10.1177/026988110101500201

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