Antisense oligonucleotides in cutaneous therapy.

C J Wraight; P J White

doi:10.1016/s0163-7258(01)00133-4

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Antisense oligonucleotides in cutaneous therapy.

C J Wraight·P J White

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Abstract

Antisense oligonucleotides have been the subject of intense interest as research tools to elucidate the functions of gene products and as therapeutic agents. Initially, their mode of action was poorly understood and the biological effects of oligonucleotides were often misinterpreted. However, research into these gene-based inhibitors of cellular action recently has succeeded in realising their exciting potential, particularly as novel therapeutic agents. An emerging application of this technology is in cutaneous therapy. The demand for more effective dermatological drugs will ensure further development of antisense strategies in skin, with key issues being drug delivery, therapeutic target selection, and clinical applicability.

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Antineoplastic Agents Antiviral Agents Dermatologic Agents Drug Delivery Systems Drug Design Genetic Therapy Humans Molecular Structure Oligonucleotides, Antisense RNA, Messenger Skin Diseases Skin Neoplasms Thionucleotides Journal Article Research Support, Non-U.S. Gov't Review

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C J Wraight, P J White. 2001. Antisense oligonucleotides in cutaneous therapy.. https://doi.org/10.1016/s0163-7258(01)00133-4

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