T cell death and memory.

J Sprent; D F Tough

doi:10.1126/science.1062416

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T cell death and memory.

J Sprent·D F Tough

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Abstract

In typical immune responses, contact with antigen causes naive T cells to proliferate and differentiate into effector cells. After the pathogen is destroyed, most effector T cells are eliminated-thereby preserving the primary T cell repertoire-but some cells survive and form long-lived memory cells. During each stage of this process, the life or death fate of T cells is strictly regulated.

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Animals Cell Death Cell Survival Cytokines Immunologic Memory Infections T-Lymphocytes Journal Article Research Support, U.S. Gov't, P.H.S.Review

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J Sprent, D F Tough. 2001-07-13. T cell death and memory.. https://doi.org/10.1126/science.1062416

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