On relationship inference using gamete identity by descent data.

H Zhao; F Liang

doi:10.1089/106652701300312940

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On relationship inference using gamete identity by descent data.

H Zhao·F Liang

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Abstract

Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Poisson process, we show that the exact calculation of the likelihood of a particular relationship for a given gamete IBD datum is tractable. Greatgrandparent--greatgrandchild and cousin relationships are used as examples to illustrate our methods.

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Computer Simulation Female Germ Cells Humans Likelihood Functions Male Models, Genetic Mothers Paternity Pedigree Poisson Distribution Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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H Zhao, F Liang. 2001. On relationship inference using gamete identity by descent data.. https://doi.org/10.1089/106652701300312940

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