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PubMed · 11458504

Dendritic cell development from common myeloid progenitors.

M G Manz·D Traver·K Akashi·M Merad·T Miyamoto·E G Engleman·I L Weissman
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Abstract

Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeloid or lymphoid hematopoietic origins. In this model, CD8 alpha+ Mac-1- DCs are supposed to be of lymphoid while CD8 alpha- Mac-1+ DCs are supposed to be of myeloid origin. Here we summarize our findings that both CD8 alpha+ and CD8 alpha- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8 alpha expression DCs does not indicate a lymphoid origin and differences among CD8 alpha+ and CD8 alpha- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.

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AnimalsAntigens, DifferentiationBone Marrow CellsCD8 AntigensCell DifferentiationCell LineageClone CellsDendritic CellsHematopoietic Stem Cell TransplantationHematopoietic Stem CellsMacrophage-1 AntigenMiceMyeloid CellsRadiation ChimeraThymus GlandTranscription FactorsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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M G Manz, D Traver, K Akashi, M Merad, T Miyamoto, E G Engleman, I L Weissman. 2001. Dendritic cell development from common myeloid progenitors.. https://doi.org/10.1111/j.1749-6632.2001.tb03586.x

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