PubMed · 11467167
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M Reichert, J K Schultz. 2001. CJD: how to process instruments.. https://pubmed.ncbi.nlm.nih.gov/11467167/
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Amongst fears about iatrogenic transmission of new variant Creutzfeldt-Jakob disease (vCJD), last year the Department of Health of the U.K. advised that all adenotonsillectomies be performed using disposable instruments. Following implementation of these guidelines, many consultants reported an increase in post-tonsillectomy haemorrhage in association with the use of disposable instruments. We have undertaken a retrospective study of tonsillectomy and have confirmed a significant increase in the incidence of return to the theatre for arrest of postoperative haemorrhage (5.32% vs. 2.18%) during the period when disposable instruments were used.
BACKGROUND: Past projections of the future course of the vCJD epidemic in the UK have shown considerable uncertainty, with wide confidence bounds. However, recent vCJD case data have indicated a decrease in the annual incidence of deaths over the past two years. METHODS: A detailed survival model is fitted to the 121 vCJD deaths reported by the end of 2002 stratified by age and calendar time to obtain projections of future incidence. The model is additionally fitted to recent results from a survey of appendix tissues. RESULTS: Our results show a substantial decrease in the uncertainty of the future course of the primary epidemic in the susceptible genotype (MM-homozygous at codon 129 of the prion protein gene), with a best estimate of 40 future deaths (95% prediction interval 9-540) based on fitting to the vCJD case data alone. Additional fitting of the appendix data increases these estimates (best estimate 100, 95% prediction interval 10-2,600) but remains lower than previous projections. CONCLUSIONS: The primary vCJD epidemic in the known susceptible genotype in the UK appears to be in decline.
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