Combinatorial approaches to affinity chromatography.

C R Lowe

doi:10.1016/s1367-5931(00)00199-x

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Combinatorial approaches to affinity chromatography.

C R Lowe

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Abstract

A new armoury of protein purification tools is required to support rapid advances in high-throughput genomics and proteomics, which are predicted to lead to the discovery, isolation, characterisation and manufacture of a number of new biopharmaceutical proteins. Computer-aided molecular design, combinatorial (bio)chemistry and high-throughput screening techniques are now being exploited to identify highly selective ligands for use in the purification of these proteins by affinity chromatography.

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Chromatography, Affinity Combinatorial Chemistry Techniques Ligands Protein Isoforms Journal Article Review

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C R Lowe. 2001. Combinatorial approaches to affinity chromatography.. https://doi.org/10.1016/s1367-5931(00)00199-x

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