Tissue factor: an enzyme cofactor and a true receptor.

J H Morrissey

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PubMed · 11487043

Tissue factor: an enzyme cofactor and a true receptor.

J H Morrissey

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Abstract

Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many--perhaps most--thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.

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J H Morrissey. 2001. Tissue factor: an enzyme cofactor and a true receptor.. https://pubmed.ncbi.nlm.nih.gov/11487043/

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