PubMed · 11493930
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N H Shear. 2001. Q & A about this issue.. https://pubmed.ncbi.nlm.nih.gov/11493930/
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Precision oncology relies on integrating tumour fraction, variant allele frequency, clonal haematopoiesis of indeterminate potential assessment, pathogenicity, and clinical context into next-generation sequencing interpretation, enabling biologically informed and clinically meaningful treatment decisions while reducing the risk of overinterpreting nontumour or nonactionable genomic alterations.