CD1-specific T cells in microbial immunity.

J E Gumperz; M B Brenner

doi:10.1016/s0952-7915(00)00243-0

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PubMed · 11498304

CD1-specific T cells in microbial immunity.

J E Gumperz·M B Brenner

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Abstract

Recent results strengthen evidence that CD1-restricted T cells play important roles in host defense against microbial infections. Human subjects recently infected with Mycobacterium tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a synthetic glycolipid antigen results in improved immune responses to several infectious pathogens.

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Animals Antigen Presentation Antigens, CD1 Humans Infections Killer Cells, Natural Lipids Models, Biological Receptors, Antigen, T-Cell Receptors, Antigen, T-Cell, gamma-delta T-Lymphocyte Subsets Tuberculosis, Pulmonary Journal Article Research Support, U.S. Gov't, P.H.S.Review

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J E Gumperz, M B Brenner. 2001. CD1-specific T cells in microbial immunity.. https://doi.org/10.1016/s0952-7915(00)00243-0

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