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PubMed · 11499490

Solid-phase analysis method for (S)-[18F]fluorocarazolol and its metabolites.

R F Muzic·B Landmeier·Z Zhang·L Zheng·M S Berridge
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Abstract

(S)-[18F]Fluorocarazolol is a radiopharmaceutical developed to quantitatively assess beta-adrenergic receptors in vivo via positron emission tomography imaging. Since radioactive metabolites of (S)-[18F]fluorocarazolol rapidly appear in the plasma, methods for conveniently and reliably evaluating plasma for (S)-[18F]fluorocarazolol content are required. Here we present methods and validation of an approach using commercial extraction cartridges that is faster and more convenient than an approach using internal-surface reverse-phase chromatography but yields comparable results.

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Adrenergic beta-AntagonistsCarbazolesChromatography, High Pressure LiquidPropanolaminesRadiopharmaceuticalsSensitivity and SpecificityJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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R F Muzic, B Landmeier, Z Zhang, L Zheng, M S Berridge. 2001-08-15. Solid-phase analysis method for (S)-[18F]fluorocarazolol and its metabolites.. https://doi.org/10.1016/s0378-4347(01)00233-x

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