Interferon-alpha in inflammation and immunity.

A Kaser; H Tilg

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PubMed · 11502069

Interferon-alpha in inflammation and immunity.

A Kaser·H Tilg

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Abstract

Type I interferons, constituting IFN-alpha and IFN-beta, were initially described for their ability to interfere with viral replication. IFN-alpha was the first cytokine to be cloned and used successfully as a therapeutic cytokine, although its mechanism of action remained largely elusive. Evidence gathered over the last few years shed light on the molecular effects of IFN-alpha, especially its interaction with the cytokine cascade. Recently, the principle source of IFN-alpha could be identified as the precursor of type 2 dendritic cells, and IFN-alpha has been identified as the cytokine linking innate with adaptive immunity via its interaction with dendritic cells.

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Animals Anti-Inflammatory Agents Apoptosis Dendritic Cells Humans In Vitro Techniques Inflammation Inflammation Mediators Interferon Type I Interferon-alpha Recombinant Proteins T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Review

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A Kaser, H Tilg. 2001. Interferon-alpha in inflammation and immunity.. https://pubmed.ncbi.nlm.nih.gov/11502069/

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