Agonist concentration gradients as a generalizable regulatory implementation strategy.

E J Calabrese; L A Baldwin

doi:10.1080/20014091111758

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PubMed · 11504174

Agonist concentration gradients as a generalizable regulatory implementation strategy.

E J Calabrese·L A Baldwin

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Abstract

This article proposes a general mechanism by which biphasic dose-response relationships occur in pharmacological and toxicological experimental systems. Such biphasic responses are mediated via a strategy of differential binding to stimulatory and inhibitory receptor subtypes based on agonist concentrations. Such a strategy is widely seen in pharmacological systems and has been demonstrated in toxicological-related biphasic dose responses in which the treatment altered levels of endogenous agonists.

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Adaptation, Physiological Animals Dose-Response Relationship, Drug Homeostasis Humans Models, Theoretical Pharmacology Signal Transduction Toxicity Tests Journal Article

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E J Calabrese, L A Baldwin. 2001. Agonist concentration gradients as a generalizable regulatory implementation strategy.. https://doi.org/10.1080/20014091111758

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