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PubMed · 11504186

Cell migration/chemotaxis: biphasic dose responses.

E J Calabrese
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Abstract

The dose-dependent effects of chemoattractants on target cell migration such as tumor cells, fibroblasts, and especially neutrophils were assessed. In general, the dose-response characteristics were strikingly biphasic in nature and were independent of both the target tissue and chemoattractant agent. The assessment included evaluations of the quantitative features of the dose-response relationship, mechanistic foundations of the biphasic responsiveness and clinical applications.

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AlcoholsAnimalsCell MovementChemotaxisDose-Response Relationship, DrugFibroblastsGanglionic StimulantsHumansMiceNeoplasmsNeoplastic Cells, CirculatingNerve Growth FactorNeutrophilsNicotinePentoxifyllinePlatelet Aggregation InhibitorsPlatelet-Derived Growth Factoralpha 1-AntitrypsinJournal ArticleReview

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E J Calabrese. 2001. Cell migration/chemotaxis: biphasic dose responses.. https://doi.org/10.1080/20014091111875

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