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PubMed · 11514138

Parallel solid-phase synthesis of nucleoside phosphoramidate libraries.

Y Jin·X Chen·M Côté·A Roland·B Korba·S Mounir·R P Iyer
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Abstract

Combinatorial chemistry is playing an increasingly prominent role in the process of drug discovery. A nucleic acid-based (NAB) scaffold can be engineered to create functional group and topological diversity in a library. Described herein is the parallel solid-phase synthesis of combinatorial libraries of nucleoside phosphoramidates, and the first evaluation of antiviral activity against hepatitis B virus (HBV).

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AmidesAntiviral AgentsChromatography, High Pressure LiquidHepatitis B virusMicrobial Sensitivity TestsNucleotidesPhosphoric AcidsJournal Article

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Y Jin, X Chen, M Côté, A Roland, B Korba, S Mounir, R P Iyer. 2001-08-20. Parallel solid-phase synthesis of nucleoside phosphoramidate libraries.. https://doi.org/10.1016/s0960-894x(01)00380-8

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