Polymeric microspheres composed of pH/temperature-sensitive polymer complex.

E J Kim; S H Cho; S H Yuk

doi:10.1016/s0142-9612(00)00439-7

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Polymeric microspheres composed of pH/temperature-sensitive polymer complex.

E J Kim·S H Cho·S H Yuk

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Abstract

A new pH/temperature-sensitive polymer system with transitions resulting both from polymer-water and polymer-polymer interactions has been demonstrated using the mixture of poly(N,N-dimethylamino)ethyl methacrylate (DMAEMA) and polyethyl acrylamide (EAAm). Based on the pH/temperature sensitivity of polymer mixture, the microsphere for pH/temperature-sensitive drug release have been designed and characterized. Hydrocortisone was used as a model drug. This gave the control of hydrocortisone release in an on-off manner without considerable lag time.

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Biocompatible Materials Drug Delivery Systems Hydrocortisone Hydrogen Bonding Hydrogen-Ion Concentration Materials Testing Methacrylates Microspheres Nylons Polymers Temperature Thermodynamics Water Journal Article Research Support, Non-U.S. Gov't

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E J Kim, S H Cho, S H Yuk. 2001. Polymeric microspheres composed of pH/temperature-sensitive polymer complex.. https://doi.org/10.1016/s0142-9612(00)00439-7

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