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Histone variants: are they functionally heterogeneous?

D T Brown
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Abstract

In most eukaryotes, histones, which are the major structural components of chromatin, are expressed as a family of sequence variants encoded by multiple genes. Because different histone variants can contribute to a distinct or unique nucleosomal architecture, this heterogeneity can be exploited to regulate a wide range of nuclear functions, and evidence is accumulating that histone variants do indeed have distinct functions.

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AnimalsChromatinGene Expression RegulationGenetic VariationHistonesHumansMultigene FamilyNucleosomesTranscription, GeneticJournal ArticleReview

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BibTeXRIS

D T Brown. 2001-07-05. Histone variants: are they functionally heterogeneous?. https://doi.org/10.1186/gb-2001-2-7-reviews0006

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