Synaptic plasticity and nicotine addiction.

J A Dani; D Ji; F M Zhou

doi:10.1016/s0896-6273(01)00379-8

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Synaptic plasticity and nicotine addiction.

J A Dani·D Ji·F M Zhou

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Abstract

Nicotine, the main addictive component of tobacco, activates and desensitizes nicotinic acetylcholine receptors (nAChRs). In that way, nicotine alters normal nicotinic cholinergic functions. Among the myriad of psychopharmacological effects that underlie the addiction process, nicotine influences nAChR participation in synaptic plasticity. This influence has particular importance in the mesocorticolimbic dopamine system, which serves during the reinforcement of rewarding behaviors.

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Animals Cerebral Cortex Dopamine Humans Limbic System Neuronal Plasticity Neurons Nicotine Nicotinic Agonists Receptors, Nicotinic Reward Tobacco Use Disorder Journal Article Review

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J A Dani, D Ji, F M Zhou. 2001-08-16. Synaptic plasticity and nicotine addiction.. https://doi.org/10.1016/s0896-6273(01)00379-8

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