Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat.

D Aït Amara; L Segu; M C Buhot

doi:10.1016/s0304-3940(01)02080-8

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Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat.

D Aït Amara·L Segu·M C Buhot

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Abstract

The cellular location of 5-HT1A and 5-HT1B binding sites in the hippocampus was investigated using a stereotaxic unilateral lesion of the CA1 field by ibotenic acid, followed by autoradiography on brain sections with the specific ligands [3H]8-OH-DPAT and S-CM-G[125I]TNH2, respectively. As compared to the contralateral side of the lesion, the ipsilateral side exhibited a decrease in the density of 5-HT1A binding sites in the strata oriens and radiatum of CA1, and of 5-HT1B binding sites in the dorsal subiculum and stratum oriens of CA1. The results demonstrate that 5-HT1A binding sites are located on dendrites whereas 5-HT1B binding sites are located on axon terminals of CA1 pyramidal cells.

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8-Hydroxy-2-(di-n-propylamino)tetralin Animals Autoradiography Binding Sites Excitatory Amino Acid Agonists Hippocampus Ibotenic Acid Injections Injections, Intraperitoneal Male Neurons Rats Rats, Long-Evans Receptor, Serotonin, 5-HT1B Receptors, Serotonin Receptors, Serotonin, 5-HT1 Journal Article

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D Aït Amara, L Segu, M C Buhot. 2001-09-07. Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat.. https://doi.org/10.1016/s0304-3940(01)02080-8

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