Pathophysiologic consequences of hydrocephalus.

M R Del Bigio

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PubMed · 11524286

Pathophysiologic consequences of hydrocephalus.

M R Del Bigio

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Abstract

Hydrocephalus-induced damage is dependent on the rate and magnitude of ventricular dilatation, the proximity to the ventricle, and the developmental stage at which the disturbance occurs. It is mediated through a combination of mechanical, ischemic, and metabolic-toxic disturbances. Developmental processes, including myelin production, can be impaired. Periventricular axons are the primary target, however. The potential for reversal of damage by shunting diminishes as the duration and severity of hydrocephalus increases. Ancillary pharmacologic means for preventing hydrocephalus-induced brain damage are worth pursuing.

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Animals Brain Cerebral Cortex Cerebrospinal Fluid Pressure Humans Hydrocephalus Intracranial Pressure Nerve Degeneration Regional Blood Flow Journal Article Research Support, Non-U.S. Gov't Review

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M R Del Bigio. 2001. Pathophysiologic consequences of hydrocephalus.. https://pubmed.ncbi.nlm.nih.gov/11524286/

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