ABT-761 (Abbott).

J J Reid

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PubMed · 11527015

ABT-761 (Abbott).

J J Reid

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Abstract

Abbott's ABT-761 is a 5-lipoxygenase inhibitor with 8-fold increased potency over Bay-X-1005 and 150-fold over zileuton [171665]. It has a longer duration of action than its closest competitor, ZD-2138 (AstraZeneca), and has entered phase III trials for asthma [224216]. ABT-761 is the follow-up compound for zileuton and, due to its increased potency, requires only once-daily dosing [187700]. ABT-761 has shown excellent oral bioavailability and an extended duration of plasma levels in man, and initial results for a single 200 mg po dose have shown a significant protective effect against exercise- and adenosine-induced bronchoconstriction in asthmatics [215839]. The drug is well tolerated in healthy volunteers and shows linear pharmacokinetics. The pharmacokinetics in children are similar to that of adults.

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Asthma Clinical Trials, Phase III as Topic Humans Hydroxyurea Lipoxygenase Inhibitors Journal Article

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J J Reid. 2001. ABT-761 (Abbott).. https://pubmed.ncbi.nlm.nih.gov/11527015/

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