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PubMed · 11532392

Hematopoietic development: a balancing act.

A B Cantor·S H Orkin
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Abstract

Over the past year, significant new insights have been gained in our understanding of the lineage determination of red blood cells. In particular, evidence has emerged demonstrating that cross-antagonism of lineage-specific transcription factors plays an important role in determining cell phenotype by actively repressing alternate lineage gene programs.

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AnimalsCarrier ProteinsCell DifferentiationCell LineageDNA-Binding ProteinsErythroid-Specific DNA-Binding FactorsHematopoiesisHematopoietic Stem CellsHumansNuclear ProteinsProto-Oncogene ProteinsTrans-ActivatorsTranscription FactorsProto-Oncogene Protein Spi-1Journal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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A B Cantor, S H Orkin. 2001. Hematopoietic development: a balancing act.. https://doi.org/10.1016/s0959-437x(00)00226-4

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