Lymphocyte development from hematopoietic stem cells.

M Kondo; D C Scherer; A G King; M G Manz; I L Weissman

doi:10.1016/s0959-437x(00)00227-6

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PubMed · 11532393

Lymphocyte development from hematopoietic stem cells.

M Kondo·D C Scherer·A G King·M G Manz·I L Weissman

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Abstract

The recent application of new techniques, such as multi-color cell sorting and the production of transgenic and gene-knockout mice, has contributed to a better understanding of lymphocyte development from hematopoietic stem cells. Now that we can purify progenitors at different maturational stages during lymphocyte development, the challenge is to understand the processes that govern each developmental stage transition.

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Animals Cell Differentiation Cell Lineage Dendritic Cells Gene Rearrangement Hematopoietic Stem Cells Humans Killer Cells, Natural Lymphocytes Receptors, Antigen Receptors, Cytokine Signal Transduction Transcription Factors Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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M Kondo, D C Scherer, A G King, M G Manz, I L Weissman. 2001. Lymphocyte development from hematopoietic stem cells.. https://doi.org/10.1016/s0959-437x(00)00227-6

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