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Re-evaluating centrosome function.

S Doxsey
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Abstract

Over the past 100 years, the centrosome has risen in status from an enigmatic organelle, located at the focus of microtubules, to a key player in cell-cycle progression and cellular control. A growing body of evidence indicates that centrosomes might not be essential for spindle assembly, whereas recent data indicate that they might be important for initiating S phase and completing cytokinesis. Molecules that regulate centrosome duplication have been identified, and the expanding list of intriguing centrosome-anchored activities, the functions of which have yet to be determined, promises continued discovery.

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AnimalsCell CycleCentrosomeHumansMicrotubulesNeoplasmsSpindle ApparatusJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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S Doxsey. 2001. Re-evaluating centrosome function.. https://doi.org/10.1038/35089575

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