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PubMed · 11541024

U.S. prebreathe protocol.

McBarron JW 2nd
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Abstract

This paper identifies and describes the prebreathe protocol currently used by the U.S. Space Shuttle Program to provide astronauts the capability to safely perform extravehicular activity. A comparison of planned vs actual prebreathe experience through the STS-37 Mission is also provided.

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Aerospace MedicineAtmospheric PressureDecompression SicknessExtravehicular ActivityHumansNitrogenOxygen Inhalation TherapySpace FlightSpace SuitsSpacecraftUnited StatesUnited States National Aeronautics and Space AdministrationJournal Article

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McBarron JW 2nd. 1994. U.S. prebreathe protocol.. https://doi.org/10.1016/0094-5765(94)90152-x

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The risk of venous thrombosis may be increased during aeroplane flights, which may, partly, relate to activation of coagulation by hypoxia that is caused by the reduction of pressure in the aircraft cabin. To find out whether hypoxia activates coagulation, we exposed eight healthy human participants to 8 h of isocapnic hypoxia and 8 h of air as a control. Venous blood was sampled before and after the exposure and analysed for markers of activated coagulation. There were no significant changes. We conclude that hypoxia has no major effect on coagulation in the general population.

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