Redesigning nucleic acids.

S A Benner; T R Battersby; B Eschgfaller; D Hutter; J T Kodra; S Lutz; T Arslan; D K Baschlin; M Blattler; M Egli; C Hammer; H A Held; J Horlacher; Z Huang; B Hyrup; T F Jenny; S C Jurczyk; M Konig; U von Krosigk; M J Lutz; L J MacPherson; S E Moroney; E Muller; K P Nambiar; J A Piccirilli; C Y Switzer; J J Vogel; C Richert; A L Roughton; J Schmidt; K C Schneider; J Stackhouse

doi:10.1351/pac199870020263

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PubMed · 11542721

Redesigning nucleic acids.

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Abstract

A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did.

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Catalysis Codon DNA Molecular Biology Molecular Structure Nucleic Acids Oligonucleotides Phosphates Sulfones Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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S A Benner, T R Battersby, B Eschgfaller, D Hutter, J T Kodra, S Lutz, T Arslan, D K Baschlin, M Blattler, M Egli, C Hammer, H A Held, J Horlacher, Z Huang, B Hyrup, T F Jenny, S C Jurczyk, M Konig, U von Krosigk, M J Lutz, L J MacPherson, S E Moroney, E Muller, K P Nambiar, J A Piccirilli, C Y Switzer, J J Vogel, C Richert, A L Roughton, J Schmidt, K C Schneider, J Stackhouse. 1998. Redesigning nucleic acids.. https://doi.org/10.1351/pac199870020263

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