Hematological and immunological changes during space flight.

A Cogoli

doi:10.1016/0094-5765(81)90070-9

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Hematological and immunological changes during space flight.

A Cogoli

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Abstract

This paper gives a summary of the principal hematological and immunological changes observed in crews after space flight. Reduction of red blood cell mass (2-21%) and of hemoglobin mass (12-33%) is generally observed after the US and Soviet space missions. The changes are accompanied with a loss of plasma volume (4-16%). Erythrocyte and hemoglobin concentrations in the blood remain constant, suggesting that the changes are driven by a feed-back mechanism. Immunological changes consist mainly of reduced T-lymphocyte reactivity. The results of the 96-day and 140-day Salyut-6 missions suggest that the adaptation of the immune system to spaceflight occurs in two stages: the first takes place during the first 2-3 months in space, the second follows and consists of further weakening of the immune response. Our experiments with human lymphocytes in vitro indicate that high-g enhance, whereas low-g depress lymphocyte activity. Finally, our investigations to be performed on Spacelab are described.

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Adaptation, Physiological Blood Physiological Phenomena Erythrocyte Volume Hemoglobin A Humans Immune System Male Plasma Volume Reticulocyte Count Space Flight T-Lymphocytes USSR United States Weightlessness Journal Article Research Support, Non-U.S. Gov't Review

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A Cogoli. Hematological and immunological changes during space flight.. https://doi.org/10.1016/0094-5765(81)90070-9

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