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PubMed · 11544023

Anoikis mechanisms.

S M Frisch·R A Screaton
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Abstract

Anoikis is defined as apoptosis that is induced by inadequate or inappropriate cell-matrix interactions. It is involved in a wide diversity of tissue-homeostatic, developmental and oncogenic processes. The central problem of anoikis is to understand how integrin-mediated cell adhesion signals control the apoptotic machinery. In particular, the initiation of the caspase cascade in anoikis remains to be explained.

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Adaptor Proteins, Signal TransducingAnoikisCarrier ProteinsCytoskeletonFas-Associated Death Domain ProteinGrowth SubstancesHumansIntegrinsMAP Kinase Signaling SystemModels, BiologicalNeoplasmsPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesProto-Oncogene ProteinsProto-Oncogene Proteins c-aktSignal TransductionJournal ArticleReview

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S M Frisch, R A Screaton. 2001. Anoikis mechanisms.. https://doi.org/10.1016/s0955-0674(00)00251-9

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