Lutropin receptor function: insights from natural, engineered, and computer-simulated mutations.

F Fanelli; A P Themmen; D Puett

doi:10.1080/152165401753544214

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Lutropin receptor function: insights from natural, engineered, and computer-simulated mutations.

F Fanelli·A P Themmen·D Puett

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Abstract

The lutropin receptor is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimer glycoprotein hormone family. As reviewed herein, comparative analyses of natural, engineered, and computer-simulated mutations of the lutropin receptor have provided considerable insight into the molecular basis of receptor function.

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Amino Acid Sequence Computer Simulation Female Humans Male Models, Molecular Molecular Sequence Data Mutation Protein Engineering Protein Structure, Tertiary Receptors, LH Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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F Fanelli, A P Themmen, D Puett. 2001. Lutropin receptor function: insights from natural, engineered, and computer-simulated mutations.. https://doi.org/10.1080/152165401753544214

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