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PubMed · 11548860

Ofloxacin/beta-cyclodextrin complexation.

L S Koester·S S Guterres·M Le Roch·V L Eifler-Lima·J A Zuanazzi·V L Bassani
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Abstract

Ofloxacin (OFX) is a fluorquinolone characterized by photochemical instability. With the goal to improve its photostability in aqueous solutions, the complexation of ofloxacin with beta-cyclodextrin was investigated. The complexes showed a water solubility enhancement of approximately 2.6 times; nevertheless, the photodegradation of ofloxacin was not reduced. The complexes obtained were characterized by thermal and 1H nuclear magnetic resonance (NMR) analysis, which revealed an interaction between ofloxacin and beta-cyclodextrin. The last analysis indicated that only partial inclusion of the N-methylpiperazinyl moiety occurred, which can explain the fact that photostabilization was not improved. This partial inclusion phenomenon could be explained also by computer-aided molecular modeling.

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Anti-Infective AgentsCalorimetry, Differential ScanningChromatography, High Pressure LiquidComputer GraphicsCyclodextrinsDrug StabilityKineticsLightMagnetic Resonance SpectroscopyModels, MolecularOfloxacinSolubilityUltraviolet Raysbeta-CyclodextrinsJournal ArticleResearch Support, Non-U.S. Gov't

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BibTeXRIS

L S Koester, S S Guterres, M Le Roch, V L Eifler-Lima, J A Zuanazzi, V L Bassani. 2001. Ofloxacin/beta-cyclodextrin complexation.. https://doi.org/10.1081/ddc-100105178

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