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PubMed · 11549464

Solid- and solution-phase synthesis of highly-substituted-pyrrolidine libraries.

M Steger·C Hubschwerlen·G Schmid
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Abstract

Starting from a complex bicyclic beta-lactam scaffold we have demonstrated the possible production of libraries of a new class of drug-like, highly substituted pyrrolidines. The choice of the type of substitution was made by optimizing various synthetic routes. The selection of each compound is the result of a filtration of a large virtual combinatorial chemical space, using simple criteria. The access to these complex pyrrolidines needed only four to six synthetic steps.

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Chemistry, OrganicCombinatorial Chemistry TechniquesLactamsOrganic ChemicalsPyrrolidinesJournal Article

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M Steger, C Hubschwerlen, G Schmid. 2001-09-17. Solid- and solution-phase synthesis of highly-substituted-pyrrolidine libraries.. https://doi.org/10.1016/s0960-894x(01)00495-4

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