Review: what can structural classifications reveal about protein evolution?

C A Orengo; I Sillitoe; G Reeves; F M Pearl

doi:10.1006/jsbi.2001.4398

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Review: what can structural classifications reveal about protein evolution?

C A Orengo·I Sillitoe·G Reeves·F M Pearl

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Abstract

In this article we present a review of the methods used for comparing and classifying protein structures. We discuss the hierarchies and populations of fold groups and evolutionary families in some of the major classifications and we consider some of the problems confronting any general analyses of structural evolution in protein families. We also review some more recent analyses that have expanded these classifications by identifying sequence relatives in the genomes and thereby reveal interesting trends in fold usage and recurrence.

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Animals Evolution, Molecular Protein Folding Proteins Structure-Activity Relationship Comparative Study Journal Article Research Support, Non-U.S. Gov't Review

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C A Orengo, I Sillitoe, G Reeves, F M Pearl. Review: what can structural classifications reveal about protein evolution?. https://doi.org/10.1006/jsbi.2001.4398

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