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Interpretation of thyroid function tests.

C M Dayan
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Abstract

The introduction of sensitive thyrotropin assays and free thyroid hormone measurements has simplified the interpretation of thyroid function tests. However, important pitfalls and difficult cases still exist. In this review, thyroid function test results are grouped into six different patterns. We propose that if assays for thyrotropin, free T3, and free T4 are all done, knowledge of these patterns coupled with clinical details and simple additional tests allow a diagnosis to be made in almost all cases.

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Diagnostic ErrorsHumansReproducibility of ResultsThyroid DiseasesThyroid Function TestsJournal ArticleReview

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BibTeXRIS

C M Dayan. 2001-02-24. Interpretation of thyroid function tests.. https://doi.org/10.1016/s0140-6736(00)04060-5

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[Primary extranodal lymphomas: analyses of clinical characteristics and misdiagnoses of 139 cases].

OBJECTIVE: To evaluate the incidence, extranodal sites, clinical characteristics and misdiagnosis rate of primary extranodal lymphomas. METHODS: A retrospective survey of 139 patients of primary extranodal lymphomas from Peking University First Hospital was completed with a view to improving our knowledge of the incidence, extranodal sites, clinical characteristics and misdiagnosis rate of primary extranodal lymphomas. RESULTS: (1) We studied 139 patients with primary extranodal lymphoma, who constituted 30.3% of 458 patients with lymphoma in Peking University First Hospital between 12/1976 and 2/2002. (2) The developing sequence of common extranodal sites was: gastrointestinal lymphoma 20.9% (29/139), nasal lymphoma 18.7% (26/139), Waldeyer's ring lymphoma 12.9% (18/139), splenic lymphoma 10.8% (15/139), and cutaneous lymphoma 6.5% (9/139). (3) Misdiagnosis rate of primary extranodal lymphoma was 80.6%, and misdiagnosis rate of nodal lymphoma was 28.5%. (4) Symptoms and signs of extranodal lymphoma were quite different based on different extranodal sites and had no specific characteristics. CONCLUSION: Primary extranodal lymphoma is relatively common. Misdiagnosis rate is very high because extranodal sites are very extensive and signs are of no specific characteristics. We should pay more attention to primary extranodal lymphoma, and get a correct diagnosis as soon as possible.

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